Microsatellite Instability in Endometrial Carcinoma.
نویسندگان
چکیده
منابع مشابه
Microsatellite instability in endometrial polyps.
OBJECTIVE(S) To investigate the prevalence of microsatellite instability (MSI) in endometrial polyps and to evaluate whether there are clinical and histopathological parameters associated with this kind of instability. STUDY DESIGN Between September 2008 and April 2009, endometrial polyps were collected from 109 patients. MSI was evaluated using the NCI recommended markers BAT25, BAT26, D2S12...
متن کاملCauses and consequences of microsatellite instability in endometrial carcinoma.
Genetic instability of microsatellite repeat sequences [microsatellite instability (MI)] is commonly seen in tumors associated with the hereditary nonpolyposis colorectal cancer syndrome and is a result of inactivating mutations in any of several genes involved in a particular pathway of DNA mismatch repair. Sporadic (i.e., nonhereditary) manifestations of several tumor types, including colorec...
متن کاملEndometrial cancer and microsatellite instability status
Microsatellite instability (MSI) is an important factor in the development of various cancers as an identifier of a defective DNA mismatch repair system. The objective of our study was to define the association between microsatellite instability status and traditional clinicopathologic characteristics of endometrioid type adenocarcinoma. MATERIAL AND METHODS MSI status of endometrial cancer w...
متن کاملmicrosatellite instability in young women with endometrioid type endometrial cancer
background: this study was designed to determine the frequency of microsatellite instability (msi) in young iranian patients with endometrial carcinoma and to evaluate its association with histopathologic and clinical features of disease. methods : microsatellite status was analyzed in 23 patients with endometrioid type endometrial cancer who were less than 55 years. clinicopathologic characte...
متن کاملMicrosatellite instability at a tetranucleotide repeat in type I endometrial carcinoma
BACKGROUND Microsatellite instability (MSI) at tri- or tetranucleotide repeat markers (elevated microsatellite alterations at selected tetranucleotide repeat, EMAST) has been recently described. But, the underlying genetic mechanism of EMAST is unclear. This study was to investigate the prevalence of EMAST, in type I endometrial carcinoma, and to determine the correlation between the MSI status...
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ژورنال
عنوان ژورنال: Annals of Pathology and Laboratory Medicine
سال: 2020
ISSN: 2349-6983,2394-6466
DOI: 10.21276/apalm.2907